Amoxicillin is an antibacterial drug belonging to the penicillin class, which includes semisynthetic antibiotic drugs. Amoxicillin is similar to ampicillin but differs from it by the presence of a hydroxyl group. This property of Amoxicillin makes the drug more bioavailable when taken orally. Moreover, Amoxicillin is more resistant to the action of gastric juice than ampicillin, which leads to better absorption from the gastrointestinal tract and high bioavailability.
When taking Amoxicillin, penicillin penetrates into all tissues and body fluids resulting in a high therapeutic effect. There is also a direct relationship between dose ingested and the concentration of active ingredient within the body. For example, doubling the dose leads to an increase in the concentration of the active ingredient twofold.
The drug is classified as an antibacterial bactericide. The principle of action of Amoxicillin is based on the effect of specific enzymes, of which the cell walls of bacteria are composed. Without these enzymes, cell walls are destroyed and bacteria die.
Amoxicillin takes action against various types of microorganisms, both gram-positive and gram-negative.
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One tablet contains amoxicillin trihydrate in doses of 250, 500, or 1000 mg;
Administration and dosage
Dosages should be prescribed on a case-by-case basis, taking into account disease severity, the sensitivity of the pathogen to the drug, and the age of the patient. In cases of infectious and inflammatory diseases of mild severity, it is recommended to take this drug as follows:
Adults and children from 10 years of age, 250 mg three times per day. For severe infectious diseases, dosages can be increased to 500 mg three times per day.
The largest therapeutic dose (6000 mg twice daily) is recommended for frequent purulent respiratory infections.
In cases of acute uncomplicated diseases of the urinary system, this drug should be taken at 3000 mg twice with a 10-12 hour break between doses;
In cases where a dental abscess is present, take 3000 mg twice with an 8-hour break between doses.
Gonorrhea: take a single dose of 3000 mg.
The drug is prescribed to be taken irrespective of food intake. The tablet can be swallowed whole, chopped or chewed, with a glass of water.
How fast does it work
Two hours after oral administration equal to 250 mg, maximum concentration within the blood is achieved.
How long does it work
Amoxicillin is excreted from the body within 8 hours.
Age / Children
The drug is used in pediatric practice.
You should not take Amoxicillin with alcohol, as this increases the risk of side effects as well as liver and kidney dysfunction. Users should refrain from drinking alcohol even a few days after ending a course of treatment.
The drug is prescribed to be taken irrespective of food intake.
- Infections caused by microorganisms.
- respiratory organs.
- gastrointestinal tract.
- genitourinary system
- skin and soft tissues.
Hypersensitivity to penicillin. Cross-sensitivity to ß-lactam antibiotics, including cephalosporins, infectious mononucleosis, and lymphatic leukemia.
Gastrointestinal tract: nausea, loss of appetite, vomiting, abdominal distension, diarrhea, dry mouth, taste disturbance.
Rarely: discoloration of teeth (especially when applying a suspension), which should disappear after brushing teeth, itching in the anus.
Very rarely: headaches, color of tongue in black color; and in some cases pseudomembranous and hemorrhagic colitis.
Liver and biliary tract: moderate and transient increase in activity of liver transaminases.
Reactions of hypersensitivity: side effects of the skin, such as exanthema, itching, urticaria; Immediate appearance after taking the hives is evidence of an allergic reaction to amoxicillin, which is why the drug should be discontinued.
Rarely – multivariate erythema, rashes; allergic vasculitis, Stevens-Johnson syndrome, bullous and exfoliative dermatitis; and in some cases toxic epidermal necrolysis, anaphylactic shock, angioneurotic edema.
Nervous system: hyperkinesia, dizziness, seizures. Cramps can occur in patients with renal insufficiency or in those who use high doses of the drug.
Rarely affecting the urinary system: development of interstitial nephritis.
Rarely affecting hematopoiesis: agranulocytosis, hemolytic anemia, thrombocytopenia.
General disorders: there are isolated reports of the occurrence of a drug fever. Prolonged or repeated application of the drug may lead to the development of superinfections and the colonization of persistent microorganisms or yeasts that cause oral or vaginal candidiasis.
The drug can be used during pregnancy and breastfeeding while taking into account the benefit/risk for the fetus (baby).
Ability to influence the speed of reaction
Symptoms: digestive system disorder, nausea, vomiting, diarrhea. The consequence of vomiting and diarrhea may be a water-electrolyte balance.
Treatment: prescribe gastric lavage, activated charcoal, salt laxatives. Take steps to maintain water-electrolyte balance.
This drug should be used with caution in patients demonstrating allergic diathesis and asthma.
Allergic skin reactions when taking amoxicillin occur more often than with the use of other types of drugs belonging to the penicillin group, but less often than ampicillin.
There is cross-resistance to drugs of the penicillin series, cephalosporins.
Drug use should be stopped in the presence of severe diarrhea and/or characteristic of pseudomembranous colitis.