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Doxycycline is an antibiotic belonging to the tetracycline series of drugs demonstrating a wide spectrum of effects. This semi-synthetic antibiotic drug has a bacteriostatic effect on microorganisms; and it works by inhibiting the ability of microbes to multiply within the body. Doxycycline penetrates cells of microorganisms and works by blocking the synthesis of proteins.

Doxycycline demonstrates an effect on a large number of microbes and pathogens of aerobic (requiring oxygen for development) and anaerobic (can develop without access to oxygen) origins. Doxycycline is sensitive to streptococci and staphylococcus, E. coli and salmonella, dysenteric rod, Klebsiella and clostridia, pathogens of dangerous infections (cholera, plague, anthrax, and tularemia), sexually transmitted infections (syphilis, gonorrhea, chlamydia, ureaplasmosis), malarial Plasmodium and other pathogens.

A wide range of effects of Doxycycline is particularly important in cases where the causative agent of the disease was not established for one reason or another. For example, development of pneumonia can be caused by various microorganisms.
Doxycycline does not affect fungi and viruses.

Price online

 Doxycycline 100 mg 200 mg
30 pills $35 $46
60 pills $42 $60
90 pills $58 $74
120 pills $88
180 pills $146 $116
270 pills $234 $158
360 pills $322 $199

Available Dosage

Doxycycline is dispensed in the form of 100 mg capsules.
The usual dose of Doxycycline in adults is 200 mg on the first day of treatment (once or 100 mg every 12 hours); and following the drug is prescribed at a dose of 100 mg/day (once or 50 mg every 12 hours). For more severe infections (especially chronic urinary tract infections), Doxycycline should be administered at a dose of 200 mg/day over the full course of treatment.

Administration

Ingest Doxycycline prior to or immediately following a meal to reduce the risk of irritation of the esophagus and the stomach. Plenty of fluids should be consumed with Doxycycline. Simultaneous use of food (including milk) does little to affect the absorption of Doxycycline.
Capsules should be swallowed while seated upright or standing and a long time prior to going to bed in order to reduce the risk of developing irritation or ulceration of the esophagus.

The duration of the course of Doxycycline treatment should be prescribed by a doctor on a case-to-case basis. Treatment should be continued for at least 24-48 hours after symptoms disappear and normalization of body temperature.
In cases of streptococcal infections, the drug should be used for at least ten days to prevent the development of rheumatic fever or glomerulonephritis.

For adults and children aged 12 years and over with a body weight over 45 kg, for the first day of treatment of acute infections, the daily dose of Doxycycline should be 200 mg (once or 100 mg at intervals of 12 hours); and for the following days the dosage should be 100 mg/day. For the treatment of severe infections (especially chronic urological infections), a dose of 200 mg per day should be used over the full course of the treatment period.

How fast does Doxycycline work

After 2 hours after taking Doxycycline, the antibiotic reaches the maximum concentration within blood plasma and binds to plasma proteins (up to 95%).

How long does Doxycycline work

Depending on the dose, the therapeutic concentration within the blood is maintained for 15-24 hours. This allows for a dosing scheme of Doxycycline once per day.

Indications

Doxycycline is used to treat infections caused by sensitive strains of gram-positive and/or gram-negative microorganisms as well as some other microorganisms. This includes:

  • Infections of the respiratory tract such as pneumonia and other lower respiratory tract diseases caused by Streptococcus, Haemophilus influenza, Klebsiella, Mycoplasma, Chronic bronchitis, and/or sinusitis
  • Urinary tract infections caused by sensitive strains of Klebsiella, Enterobacter, as well as Escherichia coli, and/or Streptococcus faecalis
  • Sexually transmitted infections caused by Chlamydia trachomatis
  • Uncomplicated urethral and endocervical infections and rectal infections
  • Non-monocytic urethritis caused by T-mycoplasma
  • Mild chancre, inguinal granuloma, venereal granuloma
  • Gonorrhea and syphilis
  • Skin infections: acne with the need for antibiotic therapy

Treatment of infections caused by microorganisms that are sensitive to tetracycline.

  • Ophthalmic infections: infections caused by sensitive bacteria Gonococci, Staphylococci and Haemophilus influenza.
  • Rickettsial infections: a group of typhus fever, spotted fever of rocky mountains, Ku fever, Moche fever, endocarditis caused by Coxiella.
  • Other infections: ornithosis, brucellosis (when used in combination with streptomycin), cholera, bubonic plague, epidemic typhoid fever, tick-borne fever, tularemia, melioidosis.
  • Tropical malaria resistant to chloroquine.
  • Acute intestinal amebiasis (when used in combination with amebicide).
  • Leptospirosis, gas gangrene, tetanus.

Prevention of the following conditions: Japanese river fever, diarrhea (caused by Escherichia coli), leptospirosis, and/or malaria.

Contraindications

  • Hypersensitivity to tetracyclines, doxycycline, and other drug components
  • porphyria
  • severe hepatic insufficiency
  • leukopenia

Doxycycline is contraindicated for use in children under 12 years of age.

Elderly patients: dose adjustment is not required.

Alcohol consumption should not occur while on Doxycycline therapy.

Scientific reports demonstrate that the absorption of Doxycycline is different from other forms of tetracyclines, and the effectiveness of this drug is not influenced by concurrent food consumption (including milk).

Side effects

  • Increase in intracranial pressure (decreased appetite, vomiting, headache, edema of the optic nerve) as well as toxic effects on the central nervous system (dizziness or instability).
  • Noise in ears.
  • Tachycardia, edema, pericarditis, and/or hypotension.
  • Nausea, vomiting, constipation or diarrhea, abdominal pain, glossitis, dysphagia, esophagitis (including erosive), gastritis, ulceration of the stomach and duodenum, and/or enterocolitis (due to the proliferation of resistant strains of staphylococci).
  • Maculopapular rash, skin itching, urticaria, skin hyperemia, anaphylactic shock, anaphylaxis, anaphylactoid reactions, angioedema, drug lupus erythematosus, and/or Stevens-Johnson syndrome.
  • Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, and/or porphyria.
  • Jaundice, hepatitis (rare), transient increase in liver function, liver failure, increased urea concentration in the blood serum, arthralgia, myalgia, photosensitivity, exfoliative dermatitis, erythema multiforme, toxic epidermal necrolysis, serum sickness, pseudomembranous colitis, superinfection, stable change in the color of tooth enamel, inflammation in the anogenital zone, candidiasis (vaginitis, glossitis, stomatitis, proctitis), dysbiosis, and/or hot flushes.

Pregnancy/Lactation

Doxycycline use is contraindicated during pregnancy and/or lactation.

Prescription

Requires prescription.

Shelf life

Three years.

Ability to influence the speed of reaction

Patients should refrain from all activities requiring increased attention as well as the need for rapid mental and motor reaction timing.

Interaction with other drugs

Doxycycline can increase plasma concentrations of cyclosporine.
The combined use of tetracyclines and methoxyflurane (drugs for inhalation anesthesia) can lead to the development of severe renal failure (including death).

Doxycycline should not be combined with agents containing metal ions (antacids containing salts of aluminum, calcium, and magnesium, preparations containing ions of manganese, zinc, iron preparations) in connection with the formation of inactive chelates. Absorption of doxycycline inhibits cholestyramine. Barbiturates, carbamazepine, and phenytoin reduce the concentration of doxycycline in plasma serum. Doxycycline reduces the effectiveness of penicillin as well as oral contraceptives. Doxycycline use when combined with anticoagulant therapy, thorough control of blood coagulation is required (against the background of tetracyclines, the synthesis of vitamin K decreases).

Overdose

Acute overdose of antibiotics is rare. If this occurs, the use of Doxycycline should be discontinued.

6 thoughts on “Doxycycline

  1. Charlotte Irwin says:

    Doxycycline was prescribed to me by a doctor, who said that this antibiotic has the most soothing effect on the intestines. Initially, I coughed for a week and so could not sleep. I even had to get off of the bus because I demonstrated such waves of a dry cough that other passengers looked at me with horror. At first, my throat did not hurt much, so I smeared an oil solution of chlorophyllipt. Usually, this helped me to remain trouble-free. After a few days, the pain was gone, but a strong dry cough began. I felt like my mucous membrane was going to fly out of my throat with my lungs. With this, I had no temperature or runny nose. As such, I began to worry that it was something worse than a common cold and went to the doctor. The doctor prescribed me doxycycline and said to take one capsule twice a day for the first three days, with one capsule per day taken in the days subsequently. The cough markedly decreased and, after a few days, stopped. At the same time, I was pleasantly impressed by the low price of doxycycline, especially in our time of general high costs of medicines.

  2. helen says:

    Doxycycline shows itself only in a positive light if you do not take it for too long. The main thing is not to cross that line at which the drug begins to bring on more harm than benefit. The doctor prescribed me this drug to treat sinusitis. I took it, of course, but not for long. The effects of the drug quickly helped me to address the symptoms of the disease. In general, one should take it strictly according to the instructions provided, because doxycycline has a lot of side effects. This medication treats everything from simple ENT diseases to typhoid and gonorrhea. It is worth noting that I experienced no side effects, in that I did not feel sick, my head was not spinning, and no rash presented.

  3. Sue Harris says:

    I took Doxycycline for about a week when I fell ill with a sore throat. I had never faced such a disease before, so I did not even think that it may be so horrific. It’s good that my neighbor works as a nurse. She recommended that I try doxycycline and even went to the pharmacy to buy it for me. The drug helped quite quickly, and its price is pretty low. So, upon recovering, I can confidently recommend this medicine if someone needs to treat a sore throat.

  4. Emma B. Humphreys says:

    My doctor wrote me a prescription for Doxycycline for the treatment of my acne and severe staphylococcal pimples on my face. The course of treatment lasted two months. At no point in time during or following this course of treatment did I feel discomfort. I was frightened by the potential side effects of this drug, but I did not experience any. It is likely that the appearance of side effects is dependent on the individual characteristics of a person and whether the prescribed regimen is properly followed. I took this medicine every day for two months and experienced no side effects. My face completely cleared up.

  5. Tiffanie J says:

    Prior to taking Doxycycline, I read a lot of consumer reviews. Therefore, so I decided to write one of my own. This medication was prescribed to me by my gynecologist. It is important to note that before taking these pills, you must always read the instructions. This drug must be taken with food and with a LOT of water. My overall impression is that Doxycycline is helpful, but only if it is taken using all of the steps specified in the instructions.

  6. Mary says:

    I had to take Doxycycline to treat facial acne. The doctor said that this should be treated at the internal level, which is why I should be taking antibiotics. Treatment with Doxycycline helped, but the side effects were very unpleasant. At first, I felt a little dizzy and then started to feel sick. Along with a complex therapy involving tablets, I was also prescribed some ointments. After a course of this treatment regime, the state of my acne became much better. Therefore, I able to say this treatment course helped me to get rid of my problem completely.

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