Prednisone is an anti-inflammatory, anti-allergic, antitoxic, and anti-shock drug. This drug is a synthetic analog of the hormones cortisone and hydrocortisone, which are secreted by the adrenal cortex. When this medication is ingested, it is 4-5 times more effective than cortisone and about 3 times more than hydrocortisone. Prednisone causes a slight increase in the release of potassium but does not cause a delay in sodium and water in the human body. Prednisone affects protein, water-electrolyte, carbohydrate, and fat metabolism in the human body.

Available Dosage

Prednisone is offered in oral tablets of 1, 5, 20, or 50 mg of active substance.

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Dosing of Prednisone is determined on a case-to-case basis. When determining the proper dose, it is necessary to consider a daily secretory rhythm of glucocorticosteroids. For example, in the morning patients should take a large (or all) part of the dose. Treatment should be stopped slowly by gradually reducing the dose.

When administered as a substitute therapy, the initial dose of Prednisone for adults is 20-30 mg/day (4-6 tablets); combined with a maintenance dose of 5-10 mg/day (1-2 tablets). If necessary, the initial dose of Prednisone may be 15-100 mg/day (3-20 tablets), with maintenance doses at 5-15 mg/day (1-3 tablets). The daily dose should be reduced gradually. After the end of Prednisone treatment, it is not abnormal for patients to possibly experience a withdrawal syndrome, adrenal insufficiency, and exacerbation of disease.

The maximum concentration in blood plasma is reached 60-90 minutes after administration.

The half-life is 2-4 hours.

Prednisone for children

Prednisone can be used in pediatric practice. In maturing children, glucocorticosteroids can be used only in absolute indications and under the careful supervision of a doctor.


Acute rheumatic fever, rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, systemic vasculitis, systemic scleroderma, ankylosing spondylitis, chorea; Addison’s disease, acute adrenocortical insufficiency, adrenogenital syndrome; nonspecific ulcerative colitis, Crohn’s disease, hepatitis; glomerulonephritis, lipoid nephrosis; agranulocytosis, various forms of leukemia, lymphogranulomatosis, thrombocytopenic purpura, hemolytic anemia; prevention of graft rejection reaction; bronchial asthma; acute and chronic allergic diseases, pemphigus, eczema, pruritus, exfoliative dermatitis, psoriasis, pruritus, eczema, seborrheic dermatitis, erythroderma, psoriasis, alopecia; allergic, chronic and atypical conjunctivitis and blepharitis; inflammation of the cornea with intact mucosa; acute and chronic inflammation of the anterior segment of the choroid, sclera and episclera; sympathetic ophthalmia.


Hypersensitivity, gastric or duodenal ulcer in the exacerbation phase, decompensated diabetes mellitus, severe arterial hypertension, osteoporosis, Itsenko-Cushing’s disease, vaccination period, active form of tuberculosis, glaucoma, systemic mycoses, acute viral infection, productive symptoms in mental illnesses, viral and bacterial diseases of the eyes, primary glaucoma, corneal diseases with epithelial damage, bacterial, fungal, viral skin lesions, tuberculosis, syphilis, skin tumors.

During treatment with Prednisone, alcohol should not be used.

Taking Prednisone with food can reduce digestion and digestive tract irritations.

Side effects

On the part of the endocrine system: the Cushing syndrome, weight gain, hyperglycemia, depletion of adrenal cortex function, and/or delay in sexual development in children.

On the part of the digestive system: nausea, vomiting, increased acidity of gastric juice, ulcerogenic effect, increase or decrease in appetite, flatulence, hiccough.

From the side of metabolism: increased excretion of potassium, sodium retention in the body with the formation of edema, and/or negative nitrogen balance.

From the cardiovascular system: arterial hypertension, arrhythmias, and/or bradycardia.

From the coagulating system of blood: increased coagulability of blood.

From the musculoskeletal system: steroid myopathy, muscle mass reduction, osteoporosis, aseptic necrosis of bones, growth retardation, and/or ossification processes in children.

From the skin and mucous membranes: delayed healing of wounds, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, acne, striae, and/or tendency to develop pyoderma and candidiasis.

From the side of the organ of vision: steroid cataract and/or provocation of latent glaucoma.

From the nervous system: mental disorders.

Allergic reactions: generalized (skin rash, skin itching, anaphylactic shock) local allergic reactions.

Prednisone during pregnancy

During pregnancy (especially in the first trimester) Prednisone should only be used for life indications. If Prednisone is needed during lactation, patients should carefully weigh the expected benefit of treatment to the mother against the potential risk to the child.


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Prednisone for animals

Prednisone is often used as a highly effective antiallergic drug for the treatment of cats and dogs. Prednisone can be dispensed in various forms suggesting the possibility of its use for different indications of allergies.

In addition to being used to treat various types of allergies, Prednisone can be used to inhibit inflammatory processes in the body of animals. Veterinarians use the anti-inflammatory function of Prednisone by prescribing this drug for post-operative or post-traumatic periods.

Withdrawal effect

With prolonged administration of Prednisone, it is dangerous to suddenly stop taking it! If a course of Prednisone treatment is suddenly stopped, this may result in an aggravation of disease and deterioration of the general condition of a patient. Therefore, the drug should be discontinued gradually.

Ability to influence the speed of reaction

The drug does not affect the ability to drive vehicles and/or operate machinery.


The highest daily dose recommended for adults is 0.1 g. If higher dosages are taken, there is an increased risk of harmful side effects.

Rating: 4 - 6 reviews

6 thoughts on “Prednisone

  1. Marie Hanna says:

    I discovered this drug quite recently, but I have already researched it well and understand its importance and effectiveness. It is an indispensable treatment for laryngitis! My daughter has already had this two times in two years. The first time was a terrifying experience, because, before this, she hadn’t had diseases so serious and had only caught colds a few times. With this illness, however, my child suffocates, and I do not know how to help her; thus, it’s good that the ambulance arrived so quickly. They gave her an injection of prednisone and her condition stabilized. The second time, laryngitis caught us by surprise, and we rushed to the hospital in a flash. Doctors say that, with age, it will pass, but, for now, with every cough she has, it’s scary in that it could be laryngitis again. Fortunately, we have such drugs as prednisone, which quickly alleviates this nightmarish choking.

  2. Benjamin Attenbore says:

    I’m saved only by prednisone! My diagnosis is osteoarthritis. Those who know what kind of illness this is will understand where I am coming from. I experience very severe pains. My hip joints are almost completely destroyed. At such times during which my discomfort flares up, the drug works very well, relieving my pain, and allowing some degree of movement. Of course, like any other drug, it has its side effects: in the beginning, when I first started using it, I experienced bouts of diarrhea.

  3. Louise Hill says:

    My husband had sarcoidosis and used to treat it with Medrol. He took it for six months, and then he was recommended a cheaper drug, prednisone. It’s good in that it suited him. After six months of taking these hormones, my husband became healthy! True, there were a lot of side effects: excess weight, stretches all over the body, and bad emotional state, but it was necessary to experience these sacrifices to ultimately overcome the disease.

  4. Victoria Williamson says:

    I have been suffering from idiopathic eczema for many years. There are times when the allergic reaction is particularly severe. Therefore, to alleviate acute inflammation, I have learned that you should use hormonal drugs. Usually, I use Prednisone at a dosage of 40 mg once per day over the course of five days. At the time of treatment, it is better to avoid consumption of vegetables and instead eat proteins. This is because the joint intake of Prednisone and plant foods leads to dyspeptic disorders, more precisely, flatulence. Prednisone is effective, but it also has disadvantages such as withdrawal syndrome. If the duration of drug use is more than two weeks, it is important to stop treatment slowly with gradual reductions in dosages.

  5. Adam says:

    My son is now four years old. For three of these years, he has periodically suffered from attacks of stenosis (edema) of the larynx. After he had a severe attack a year ago (in the middle of the night he began to suffocate), I studied all possible ways to treat this ailment. None of the other treatment methods (no inhalation, no hot bath, and high humidity) can match the speed and effectiveness of this Prednisone! Of course, you need to do Prednisone injections only in the most extreme cases when nothing else will help. Prednisone takes effect immediately. My son stops choking after a couple of minutes!

  6. Isabel says:

    Prednisone is a drug that should be included in the hall of fame for its effectiveness. Without this medicine, it is impossible to treat oncology at any stage. Without Prednisone, treatment of certain types of allergies associated with respiratory problems is also impossible. All of this positive information about Prednisone cannot be gleaned from books and reviews. Instead, all of this information has been passed along and tested by me and my loved ones. Prednisolone saved my father’s life more than once when he was in intensive care. The drug works to strengthen the functionality of all organs, which provides stable health, remission and allows the patient to tolerate the course of a disease.

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