Prednisone is an anti-inflammatory, anti-allergic, antitoxic, and anti-shock drug. This drug is a synthetic analog of the hormones cortisone and hydrocortisone, which are secreted by the adrenal cortex. When this medication is ingested, it is 4-5 times more effective than cortisone and about 3 times more than hydrocortisone. Prednisone causes a slight increase in the release of potassium but does not cause a delay in sodium and water in the human body. Prednisone affects protein, water-electrolyte, carbohydrate, and fat metabolism in the human body.
Prednisone is offered in oral tablets of 1, 5, 20, or 50 mg of active substance.
|Prednisone||5 mg||10 mg||20 mg||40 mg|
Dosing of Prednisone is determined on a case-to-case basis. When determining the proper dose, it is necessary to consider a daily secretory rhythm of glucocorticosteroids. For example, in the morning patients should take a large (or all) part of the dose. Treatment should be stopped slowly by gradually reducing the dose.
When administered as a substitute therapy, the initial dose of Prednisone for adults is 20-30 mg/day (4-6 tablets); combined with a maintenance dose of 5-10 mg/day (1-2 tablets). If necessary, the initial dose of Prednisone may be 15-100 mg/day (3-20 tablets), with maintenance doses at 5-15 mg/day (1-3 tablets). The daily dose should be reduced gradually. After the end of Prednisone treatment, it is not abnormal for patients to possibly experience a withdrawal syndrome, adrenal insufficiency, and exacerbation of disease.
The maximum concentration in blood plasma is reached 60-90 minutes after administration.
The half-life is 2-4 hours.
Prednisone for children
Prednisone can be used in pediatric practice. In maturing children, glucocorticosteroids can be used only in absolute indications and under the careful supervision of a doctor.
Acute rheumatic fever, rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, systemic vasculitis, systemic scleroderma, ankylosing spondylitis, chorea; Addison’s disease, acute adrenocortical insufficiency, adrenogenital syndrome; nonspecific ulcerative colitis, Crohn’s disease, hepatitis; glomerulonephritis, lipoid nephrosis; agranulocytosis, various forms of leukemia, lymphogranulomatosis, thrombocytopenic purpura, hemolytic anemia; prevention of graft rejection reaction; bronchial asthma; acute and chronic allergic diseases, pemphigus, eczema, pruritus, exfoliative dermatitis, psoriasis, pruritus, eczema, seborrheic dermatitis, erythroderma, psoriasis, alopecia; allergic, chronic and atypical conjunctivitis and blepharitis; inflammation of the cornea with intact mucosa; acute and chronic inflammation of the anterior segment of the choroid, sclera and episclera; sympathetic ophthalmia.
Hypersensitivity, gastric or duodenal ulcer in the exacerbation phase, decompensated diabetes mellitus, severe arterial hypertension, osteoporosis, Itsenko-Cushing’s disease, vaccination period, active form of tuberculosis, glaucoma, systemic mycoses, acute viral infection, productive symptoms in mental illnesses, viral and bacterial diseases of the eyes, primary glaucoma, corneal diseases with epithelial damage, bacterial, fungal, viral skin lesions, tuberculosis, syphilis, skin tumors.
During treatment with Prednisone, alcohol should not be used.
Taking Prednisone with food can reduce digestion and digestive tract irritations.
On the part of the endocrine system: the Cushing syndrome, weight gain, hyperglycemia, depletion of adrenal cortex function, and/or delay in sexual development in children.
On the part of the digestive system: nausea, vomiting, increased acidity of gastric juice, ulcerogenic effect, increase or decrease in appetite, flatulence, hiccough.
From the side of metabolism: increased excretion of potassium, sodium retention in the body with the formation of edema, and/or negative nitrogen balance.
From the cardiovascular system: arterial hypertension, arrhythmias, and/or bradycardia.
From the coagulating system of blood: increased coagulability of blood.
From the musculoskeletal system: steroid myopathy, muscle mass reduction, osteoporosis, aseptic necrosis of bones, growth retardation, and/or ossification processes in children.
From the skin and mucous membranes: delayed healing of wounds, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, acne, striae, and/or tendency to develop pyoderma and candidiasis.
From the side of the organ of vision: steroid cataract and/or provocation of latent glaucoma.
From the nervous system: mental disorders.
Allergic reactions: generalized (skin rash, skin itching, anaphylactic shock) local allergic reactions.
Prednisone during pregnancy
During pregnancy (especially in the first trimester) Prednisone should only be used for life indications. If Prednisone is needed during lactation, patients should carefully weigh the expected benefit of treatment to the mother against the potential risk to the child.
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Prednisone for animals
Prednisone is often used as a highly effective antiallergic drug for the treatment of cats and dogs. Prednisone can be dispensed in various forms suggesting the possibility of its use for different indications of allergies.
In addition to being used to treat various types of allergies, Prednisone can be used to inhibit inflammatory processes in the body of animals. Veterinarians use the anti-inflammatory function of Prednisone by prescribing this drug for post-operative or post-traumatic periods.
With prolonged administration of Prednisone, it is dangerous to suddenly stop taking it! If a course of Prednisone treatment is suddenly stopped, this may result in an aggravation of disease and deterioration of the general condition of a patient. Therefore, the drug should be discontinued gradually.
Ability to influence the speed of reaction
The drug does not affect the ability to drive vehicles and/or operate machinery.
The highest daily dose recommended for adults is 0.1 g. If higher dosages are taken, there is an increased risk of harmful side effects.