Priligy is a selective serotonin reuptake inhibitor designed to treat premature ejaculation in men.
The effectiveness of Dapoxetine (main active ingredient in Priligy) in the treatment of premature ejaculation was established in five double-blind clinical tests with a placebo control, in which a total of 6081 patients were randomized.
Available dosage
The drug is available in tablets with doses of 30 mg, 60 mg and 90 mg of the active substance dapoxetine.
Priligy/Dapoxetine Online prices
| Dosage | 30 mg | 60 mg | 90 mg |
| 10 pills | – | – | $48 |
| 20 pills | – | $42 | – |
| 30 pills | $50 | $53 | $101 |
| 60 pills | $76 | $88 | $181 |
| 90 pills | $103 | $122 | $260 |
| 120 pills | $130 | $156 | $340 |
| 180 pills | $183 | $225 | $499 |
| 270 pills | $263 | $329 | – |
| 360 pills | $343 | $432 | – |
Administration
The recommended initial dose of the drug for patients aged 18-64 years is 30 mg, which should be taken one to three hours prior to the alleged sexual intercourse. Treatment with Priligy should not begin with a dose of 60 mg.
Priligy is not intended for permanent daily use. It should be taken only in case of alleged sexual intercourse.
The drug is intended for oral administration. To avoid bitter taste, tablets should be swallowed without breaking. Tablets should be taken with plenty of water.
How fast does Priligy work?
The substance is well absorbed and reaches a peak level in the plasma after 1 hour.
How long does Priligy work
The half-life of the drug is 19 hours.
Age/children
The use of dapoxetine is not permitted for patients younger than 18 years of age. The drug Priligy is contraindicated for children due to the lack of experience in clinical use. The efficacy and safety of Priligy has not established for patients aged 65 years or older.
Priligy can be used regardless of food intake. However, in joint admission with fatty foods, the maximum level of dapoxetine decreases.
Indications
Treatment of premature ejaculation in adult men aged 18-64 years.
Contraindications
Hypersensitivity to the active substance or any auxiliary component of the drug.
Heart failure.
Cardiac ischemia.
Severe valvular heart disease.
Severe depression.
Simultaneous administration of MAO inhibitors.
Simultaneous reception of serotonin reuptake inhibitors.
Violation of liver function.
Consuming with Alcohol
Simultaneous administration of ethanol in a single dose of 0.5 g per kg did not affect the pharmacokinetics of dapoxetine (with a single intake of 60 mg of the drug). However, Priligy in combination with ethanol increases drowsiness and reduces vigilance.
Side effects
Most clinical trials have reported side effects, which include: nausea (11.0 and 22.2% in the groups receiving dapoxetine at a dose of 30 mg and 60 mg, respectively), dizziness (8 and 10.9%), headache (5.6 and 8.8%), diarrhea (3.5 and 6.9%), insomnia (2.1 and 3.9%), and fatigue (2, 0 and 4.1%). The most frequent side effects leading to withdrawal included nausea (2.2% of patients receiving Priligy) and dizziness (1.2% of patients receiving Priligy).
The drug is used in men only.
Ability to influence the speed of reaction
Priligy has a moderate influence on the ability to drive vehicles or other mechanisms. However, patients whose work is related to the management of potentially unsafe devices should use Priligy with caution, given the possible development of dizziness, fainting, orthostatic hypotension, and asthenia.
Concomitant use with other medicines for the treatment of erectile dysfunction.
There were no significant changes in the pharmacokinetics of dapoxetine during the treatment with phosphodiesterase-5 inhibitors (including Viagra and Cialis), but the combined use of these drugs should be carried out with caution, given the increased risk of orthostatic hypotension.
Overdose
In a study of the clinical pharmacology of Dapoxetine, unpredictable adverse reactions were not observed when administered in a daily dose of up to 240 mg.